游戏规则改变者鼻喷雾：一种针对所有COVID-19变种的通用防护盾

新冠病毒（SARS-CoV-2）的所有已知变种都能够有效地预防感染，这一突破性发现是由芬兰赫尔辛基大学的研究人员开发的TriSb92分子，在鼻内给予。该分子在病毒的刺突蛋白中靶向一个常见区域并抑制其功能。细胞培养和动物模型实验表明其对最新变异体的有效性，并且在室温下至少18个月保持功能。该发现已经在《自然通讯》杂志上发表，有望成为未来抗击疫情的关键工具，以预防病毒的传播和蔓延。

研究人员开发了一种分子，当鼻内给予它时，它极其有效地预防了由所有已知SARS-CoV-2变种引起的疾病。该分子可成为应对未来疫情的关键工具，因为它旨在预防病毒的传播和蔓延。在实验动物研究中，由赫尔辛基大学研究人员开发的TriSb92分子已被证实为可以有效地保护免受冠状病毒感染。该分子可以识别所有当前病毒变种共同的冠状病毒刺突蛋白中的一个区域，并抑制其功能。

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“当TriSb92分子在鼻内给予时，它极其有效地预防感染，在细胞培养实验中，它也涵盖了最新的变异体，包括XBB、BF7和BQ.1.1，”Kalle Saksela教授的研究小组博士后研究员Anna R.Mäkelä解释道。

动物模型研究还表明，与口罩不同，当将该分子喷入鼻子后，即使在接触几个小时后，它也可以预防感染。

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研究人员称，该分子在室温下至少保持18个月的完全功能状态，因此非常适合用作鼻喷雾剂。这项结果已于3月24日发表在《自然通讯》杂志上。

对未来病毒变异的期望

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尽管冠状病毒大流行的最糟糕阶段已经过去，但鼻内给予的保护可能在预防未来病毒传播方面起到至关重要的帮助。

“最新的变种有效地避开了疫苗和COVID-19疾病提供的免疫保护，而现有疫苗也无法有效地预防传播，” Mäkelä说。

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此外，鼻喷雾剂可以保护那些不从疫苗中获得足够免疫力的人，如免疫功能受损的个体和老年人，免受严重疾病的侵害。

研究人员表示，该分子也可能对SARS-CoV-2的未来动物近亲产生作用，这些近亲可能成为全新冠状病毒大流行的原因。

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“由于TriSb92分子影响的冠状

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